Faculty Research 1970 - 1979
Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.
Document Type
Article
Publication Date
1978
Keywords
Chromosomes: me, Crosses-Genetic, Genes-Regulator, Mice, Mice-Inbred-Strains, Recombination-Genetic, Renin: ge, me, Submandibular-Gland: en, SUPPORT-U-S-GOVT-P-H-S
First Page
5623
Last Page
5626
JAX Source
Proc-Natl-Acad-Sci-USA. 1978 Nov; 75(11):5623-6.
Abstract
Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.
Recommended Citation
Wilson CM,
Erd:os EG,
Wilson JD,
Taylor BA.
Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse. Proc-Natl-Acad-Sci-USA. 1978 Nov; 75(11):5623-6.