Faculty Research 1970 - 1979

Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.

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Chromosomes: me, Crosses-Genetic, Genes-Regulator, Mice, Mice-Inbred-Strains, Recombination-Genetic, Renin: ge, me, Submandibular-Gland: en, SUPPORT-U-S-GOVT-P-H-S

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Proc-Natl-Acad-Sci-USA. 1978 Nov; 75(11):5623-6.


Renin activity (EC was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.

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