Faculty Research 1970 - 1979


Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme.

Document Type


Publication Date



Animal, Chromosome-Mapping, Crosses-Genetic, Genes-Structural, Intestines: en, Isoenzymes: ge, Kidney: en, Liver: en, Manganese: me, Mice, Mice-Inbred-Strains: ge, Recombination-Genetic, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Variation-(Genetics)

JAX Source

Biochem-Genet. 1979 Dec; 17(11-12):1093-107.


Genetic variation among inbred strains is described for electrophoretic migration of alkaline phosphatase from intestine, kidney, blood plasma, and three isozymes of liver. A manganese-requiring isozyme of liver and kidney unaffected by neuraminidase is described, and the locus controlling variation in this isozyme is designated Akp-1. Data from recombinant inbred strains place the locus on chromosome 1 at a distance of 3.6 +/- 2.9 cM from the M1s locus on the side distal to the centromere. Test-cross data show the following gene order and recombination percentages: Dip-1 19.0 +/- 3.8% Lp 7.4 +/- 2.2% Akp-1.

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