Faculty Research 1980 - 1989
Characterization of the AdhSL regulatory mutation in Drosophila melanogaster.
Document Type
Article
Publication Date
1988
Keywords
Animal, Drosophila-Melanogaster: en, ge, DNA-Restriction-Enzymes, Gene-Expression-Regulation, Genes-Regulator, Genes-Structural, Mutation, Nucleotide-Mapping, RNA-Messenger: ge, SUPPORT-U-S-GOVT-P-H-S, Transcription-Genetic
First Page
631
Last Page
637
JAX Source
Genetics 1988 Jul; 119(3):631-7.
Grant
AA06398, 1-T32-HD-07299-01
Abstract
We describe the characterization of a previously reported control mutation, AdhSL, in the alcohol dehydrogenase gene of Drosophila melanogaster, which results in decreased production of ADH molecules and subsequently lower ADH activity in adults. We find that the regulatory element modifies ADH mRNA levels and acts cis on both ADH protein and mRNA. It is not promoter specific but is developmentally specific to the adult stage. The AdhSL allele carries a 4.5-kb insert approximately 3 kb 5' to the distal promoter. This new insertion may be responsible for the regulatory phenotype of AdhSL.
Recommended Citation
Schott DR,
East PD,
Paigen K.
Characterization of the AdhSL regulatory mutation in Drosophila melanogaster. Genetics 1988 Jul; 119(3):631-7.