Faculty Research 1980 - 1989

Title

Characterization of the AdhSL regulatory mutation in Drosophila melanogaster.

Document Type

Article

Publication Date

1988

Keywords

Animal, Drosophila-Melanogaster: en, ge, DNA-Restriction-Enzymes, Gene-Expression-Regulation, Genes-Regulator, Genes-Structural, Mutation, Nucleotide-Mapping, RNA-Messenger: ge, SUPPORT-U-S-GOVT-P-H-S, Transcription-Genetic

JAX Source

Genetics 1988 Jul; 119(3):631-7.

Grant

AA06398, 1-T32-HD-07299-01

Abstract

We describe the characterization of a previously reported control mutation, AdhSL, in the alcohol dehydrogenase gene of Drosophila melanogaster, which results in decreased production of ADH molecules and subsequently lower ADH activity in adults. We find that the regulatory element modifies ADH mRNA levels and acts cis on both ADH protein and mRNA. It is not promoter specific but is developmentally specific to the adult stage. The AdhSL allele carries a 4.5-kb insert approximately 3 kb 5' to the distal promoter. This new insertion may be responsible for the regulatory phenotype of AdhSL.

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