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Faculty Research 1980 - 1989
The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor.
Document Type
Article
Publication Date
1981
Keywords
Antibody-Producing-Cells: im, Chromosome-Mapping, Female, Hemolytic-Plaque-Technic, Immunoglobulin-Allotypes: ge, Immunoglobulin-Constant-Region: ge, Immunoglobulins-Heavy-Chain: ge, Isoantigens, Linkage-(Genetics), Mice, Mice-Inbred-A, Mice-Inbred-AKR, Mice-Inbred-BALB-C, Mice-Inbred-C57BL, Receptors-Antigen-T-Cell: ge, Recombination-Genetic, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Suppressor-Cells: im
First Page
801
Last Page
810
JAX Source
J-Exp-Med. 1981 Apr 1; 153(4):801-10.
Grant
AI15262, AI13797, CA06927, +
Abstract
The mouse T cell alloantigen, Tsud, is expressed on a minority of mature, Lyt-2+ cells, and its expression is controlled by a gene linked to the immunoglobulin heavy chain gene cluster, Igh. Tsud can be assayed by immunofluorescence staining with an antiserum made in BALB/c mice against C.AL-20 concanavalin A blasts. This antiserum can also be used to induced T suppressor cells in mice expressing Tsu(d). Both of these assays were used to type several panels of recombinant inbred strains and Igh recombinant strains to accurately map the Tsu(d) locus. The Tsu(d) gene is located very near the heavy chain constant-region genes, Igh-C, on the side toward the prealbumin gene, Pre-1. Tsu(d) is not among the heavy chain variable-region genes, Igh-V, and thus is not a variable-region framework allotype, subgroup determinant, or idiotype. The map position suggest that the Tsu(d) antigen is a constant region allotypic determinant on the as yet uncharacterized T cell receptor.
Recommended Citation
Owen FL,
Riblet R,
Taylor BA.
The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor. J-Exp-Med. 1981 Apr 1; 153(4):801-10.