Faculty Research 1980 - 1989

Monaural and binaural audiogenic seizures in mice.

Document Type

Article

Publication Date

1989

Keywords

Animal, Dominance-Cerebral, Male, Mice, Mice-Inbred-Strains, Reaction-Time, Seizures: et, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

First Page

136

Last Page

144

JAX Source

Behav Neural Biol 1989 Mar; 51(2):136-44.

Grant

GM23618

Abstract

The progression of sound-induced seizures was examined in unilaterally or bilaterally sensitized SJL/J mice tested either monaurally or binaurally. An unexpected right-side advantage for becoming susceptible to audiogenic seizure was observed. In addition, two distinct patterns of seizure progression were noted, a uniphasic sequence in which a single burst of running preceded the convulsion and a biphasic pattern with two such bursts. The biphasic progression is viewed to be the result of unilaterally initiated seizures and characteristically reached only a clonic level of severity. Uniphasic seizures are concluded to be the result of bilaterally initiated seizures and, when they occurred after more than 30 s of auditory stimulation, frequently reached a tonic level of intensity. The present results support the view that audiogenic seizures are characterized by precisely timed, sequential processes dependent upon the specific priming and test procedures employed.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS