Monaural and binaural audiogenic seizures in mice.
Animal, Dominance-Cerebral, Male, Mice, Mice-Inbred-Strains, Reaction-Time, Seizures: et, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S
Behav Neural Biol 1989 Mar; 51(2):136-44.
The progression of sound-induced seizures was examined in unilaterally or bilaterally sensitized SJL/J mice tested either monaurally or binaurally. An unexpected right-side advantage for becoming susceptible to audiogenic seizure was observed. In addition, two distinct patterns of seizure progression were noted, a uniphasic sequence in which a single burst of running preceded the convulsion and a biphasic pattern with two such bursts. The biphasic progression is viewed to be the result of unilaterally initiated seizures and characteristically reached only a clonic level of severity. Uniphasic seizures are concluded to be the result of bilaterally initiated seizures and, when they occurred after more than 30 s of auditory stimulation, frequently reached a tonic level of intensity. The present results support the view that audiogenic seizures are characterized by precisely timed, sequential processes dependent upon the specific priming and test procedures employed.
Reid, H M. and Collins, R L., " Monaural and binaural audiogenic seizures in mice." (1989). Faculty Research 1980 - 1989. 1078.
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