Faculty Research 1980 - 1989

Y chromosome evolution in the subgenus Mus (genus Mus).

Document Type

Article

Publication Date

1989

Keywords

Autoradiography, Base-Sequence, Blotting-Southern, Comparative-Study, DNA: ip, DNA-Restriction-Enzymes, Evolution, Mice, Mice-Inbred-C57BL, Muridae: ge, Nucleic-Acid-Hybridization, SUPPORT-U-S-GOVT-P-H-S, Y-Chromosome

First Page

169

Last Page

179

JAX Location

1805

Grant

HD07065, GM20919

Abstract

A 305 base pair DNA sequence isolated from the Y chromosome of the inbred mouse strain C57BL/10 was used to investigate the pattern and tempo of evolution of Y chromosome DNA sequences for five species in the subgenus Mus, including Mus spretus, Mus hortulanus, Mus abbotti, Mus musculus and Mus domesticus. Variation in hybridization patterns between species was characterized by differences in fragment lengths of both intensely and faintly hybridizing fragments, whereas variation in hybridization patterns within species was characterized primarily by differences in fragment lengths of faintly hybridizing fragments. Phylogenetic analyses were conducted based on fragment size variation within and among species. Phylogenetic relationships inferred from these analyses partly agree with the phylogenetic relationships obtained from biochemical and mitochondrial DNA data. We conclude that a set of DNA sequences common to the Y chromosomes of a closely related group of species in the subgenus Mus has evolved rapidly as reflected by sequence divergence and sequence amplification.

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