Faculty Research 1980 - 1989
A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11.
Document Type
Article
Publication Date
1989
Keywords
Animal, Blotting-Southern, Chromosomes, Crosses-Genetic, Female, Genes-Homeo-Box, Genes-Reiterated, Hamsters, Hybrid-Cells, Keratin: ge, Linkage-(Genetics), Male, Mice, Mutation, Rats, Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S
First Page
454
Last Page
462
JAX Location
1892
Grant
GM32461, GM39414, AM37108, +
Abstract
Type I and type II keratins are major constituents of intermediate filaments that play a fundamental role in the cytoskeletal network. By using both somatic cell hybrids and conventional and interspecific linkage crosses, several genes encoding type I keratins, including the epidermal keratin K10, were shown to be closely linked to the homeobox-2 complex and the rex locus on mouse chromosome 11. The absence of crossovers between type I keratin-encoding genes and rex (N = 239), a locus affecting hair development, raises the possibility that mutations at rex and neighboring loci affecting skin and hair development involve type I keratin genes.
Recommended Citation
Nadeau JH,
Berger FG,
Cox DR,
Crosby JL,
Davisson MT,
Ferrara D,
Fuchs E,
Hart C,
Hunihan L,
Lalley PA.
A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11. . 1989; ():454