Faculty Research 1980 - 1989
Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor.
Document Type
Article
Publication Date
1981
Keywords
Antibodies-Neoplasm: ge, Cross-Reactions, Genes-Immune-Response, Genes-Structural, Hair-Color, Linkage-(Genetics), Mice, Mice-Inbred-BALB-C: ge, Mice-Inbred-DBA: ge, Neoplasms-Experimental: im, Phenotype, Plasmacytoma: im, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
263
Last Page
272
JAX Source
Immunogenetics. 1981; 14(3-4):263-72.
Grant
GM18684, AI07437
Abstract
Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.
Recommended Citation
Russell JH,
Dobos CB,
Graff RJ,
Taylor BA.
Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor. Immunogenetics. 1981; 14(3-4):263-72.