Faculty Research 1980 - 1989

Title

Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor.

Document Type

Article

Publication Date

1981

Keywords

Antibodies-Neoplasm: ge, Cross-Reactions, Genes-Immune-Response, Genes-Structural, Hair-Color, Linkage-(Genetics), Mice, Mice-Inbred-BALB-C: ge, Mice-Inbred-DBA: ge, Neoplasms-Experimental: im, Phenotype, Plasmacytoma: im, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Immunogenetics. 1981; 14(3-4):263-72.

Grant

GM18684, AI07437

Abstract

Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.

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