Faculty Research 1980 - 1989
Deletions in a recombinant retrovirus genome associated with its expression in embryonal carcinoma cells.
Document Type
Article
Publication Date
1989
Keywords
DNA-Viral: an, Genes-Viral, Moloney-Leukemia-Virus: ge, Proviruses: ge, Recombination-Genetic, Repetitive-Sequences-Nucleic-Acid, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Tumor-Cells-Cultured, Tumor-Stem-Cells: mi
First Page
4431
Last Page
4433
JAX Source
J Virol 1989 Oct;63(10):4431-3
Grant
CA39652
Abstract
We analyzed embryonal carcinoma cell lines infected with a recombinant Moloney murine leukemia virus. Lines that carried but did not express the neo gene retained a provirus of LTR-gag-pol-neo-LTR, where LTR is a long terminal repeat, whereas all G418-resistant lines deleted regions that included the primer binding site and the splicing donor site. This suggested the presence of multiple inhibitory elements.
Recommended Citation
Taketo M,
Shaffer DJ.
Deletions in a recombinant retrovirus genome associated with its expression in embryonal carcinoma cells. J Virol 1989 Oct;63(10):4431-3