Faculty Research 1980 - 1989
Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.
Document Type
Article
Publication Date
1981
Keywords
Base-Sequence, Cell-Transformation-Viral, Chromosome-Mapping, DNA-Viral: ge, Linkage-(Genetics), Mice, Mice-Inbred-DBA: ge, Mice-Mutant-Strains: ge, Mouse-Leukemia-Viruses: ge, Recombination-Genetic, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
370
Last Page
374
JAX Source
Nature. 1981 Oct 1; 293(5831):370-4.
Grant
CA06417
Abstract
The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted from integration of an ecotropic provirus into the mouse genome.
Recommended Citation
Jenkins NA,
Copeland NG,
Taylor BA,
Lee BK.
Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature. 1981 Oct 1; 293(5831):370-4.