Faculty Research 1980 - 1989

Title

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.

Document Type

Article

Publication Date

1981

Keywords

Base-Sequence, Cell-Transformation-Viral, Chromosome-Mapping, DNA-Viral: ge, Linkage-(Genetics), Mice, Mice-Inbred-DBA: ge, Mice-Mutant-Strains: ge, Mouse-Leukemia-Viruses: ge, Recombination-Genetic, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Nature. 1981 Oct 1; 293(5831):370-4.

Grant

CA06417

Abstract

The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted from integration of an ecotropic provirus into the mouse genome.

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