Faculty Research 1980 - 1989
Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes.
Document Type
Article
Publication Date
1981
Keywords
Adult, Age-Factors, Aged, Aryl-Hydrocarbon-Hydroxylases: bi, Child, Enzyme-Induction: de, Human, Lymphocytes: en, Male, Methylcholanthrene, Middle-Age, Probability, Seasons, SUPPORT-U-S-GOVT-P-H-S, Time-Factors
First Page
2757
Last Page
2761
JAX Source
Cancer Res 1981 Jul; 41(7):2757-61.
Grant
CP55629, CA18542
Abstract
A seasonal variation was observed when aryl hydrocarbon hydroxylase (AHH) activity was measured in the cultured lymphocytes of 977 donors over a period of 2 1/2 years. The variation was strongest in AHH activity induced by 3-methylcholanthrene and was less apparent for AHH activity in lymphocytes grown without any inducer. The period of the seasonal variation is 1 year, and maximal induced AHH activity occurs during late summer and early fall with minimal activity 6 months later. Based on the average of all individuals tested during the highest and lowest weeks, induced AHH activity can be as much as 10-fold higher during the peak season. It is not possible to tell from these experiments whether the seasonal variation is tissue specific, occurring only in lymphocytes, or characteristic of microsomal oxidases in other tissues as well.
Recommended Citation
Paigen B,
Ward E,
Reilly A,
Houten L,
Gurtoo HL,
Minowada J,
Steenland K,
Havens MB,
Sartori P.
Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes. Cancer Res 1981 Jul; 41(7):2757-61.