Faculty Research 1980 - 1989
A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12.
Document Type
Article
Publication Date
1981
Keywords
Antibodies-Monoclonal: im, Antigens-Surface: ge, im, Cell-Line, Chromosomes-Human-6-12: ul, Fibrosarcoma: im, Human, Immunodiffusion, Immunosorbent-Techniques, Linkage-(Genetics), Mice, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Teratoma: im
First Page
435
Last Page
443
JAX Source
Somatic Cell Genet 1981 Jul;7(4):435-43
Grant
CA18470, GM07511, CA10815
Abstract
A murine monoclonal antibody 602-29, subclass IgG1, that recognizes an antigenic determinant expressed by most human cells is described. Immunoprecipitation and sodium dodecyl sulfate-gel electrophoresis analysis indicate that the antigenic determinant is carried by a protein with an apparent molecular weight of 21,000. The antigen is expressed by human-mouse somatic cell hybrids, and analysis of segregants that have lost human chromosomes indicates that the gene controlling expression of the 602-29 antigen is on chromosome 12.
Recommended Citation
Andrews PW,
Knowles BB,
Goodfellow PN.
A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12. Somatic Cell Genet 1981 Jul;7(4):435-43