Faculty Research 1980 - 1989
Genetics of histocompatibility in mice. II. Survey for interactions between minor (non-H-2) antigens by skin grafting.
Document Type
Article
Publication Date
1980
Keywords
Female, Graft-Survival, Histocompatibility-Antigens: ge, im, Mice, Mice-Inbred-C57BL: ge, Models-Biological, Skin: tr, SUPPORT-U-S-GOVT-P-H-S, Transplantation-Homologous
First Page
363
Last Page
372
JAX Source
Immunogenetics. 1980; 11(4):363-72.
Grant
AI13130
Abstract
Twenty-five congenic mouse strains differing at distinguishable minor (non-H-2) histocompatibility loci were paired in 71 different combinations. F1 offspring were used as skin-graft donors for more than 4000 recipients to test whether immune responses to parental strain antigens were statistically independent. Thirty-four (48 percent) of the 71 combinations were predicted adequately by an independent response hypothesis. A simple additive model was consistent with 39 (55 percent) of the observed responses, although 18 of these were among those in agreement with the independent hypothesis. A synergistic response faster than that predicted by either the independent or additive response model was seen in 12 (17 percent) of the combinations. The remaining 5 percent were not well described by any of these models. No strain was represented with unusual frequency among those involved in synergistic interactions.
Recommended Citation
Johnson LL,
Bailey DW,
Mobraaten LE.
Genetics of histocompatibility in mice. II. Survey for interactions between minor (non-H-2) antigens by skin grafting. Immunogenetics. 1980; 11(4):363-72.