Faculty Research 1980 - 1989

Title

Genetics of histocompatibility in mice. II. Survey for interactions between minor (non-H-2) antigens by skin grafting.

Document Type

Article

Publication Date

1980

Keywords

Female, Graft-Survival, Histocompatibility-Antigens: ge, im, Mice, Mice-Inbred-C57BL: ge, Models-Biological, Skin: tr, SUPPORT-U-S-GOVT-P-H-S, Transplantation-Homologous

JAX Source

Immunogenetics. 1980; 11(4):363-72.

Grant

AI13130

Abstract

Twenty-five congenic mouse strains differing at distinguishable minor (non-H-2) histocompatibility loci were paired in 71 different combinations. F1 offspring were used as skin-graft donors for more than 4000 recipients to test whether immune responses to parental strain antigens were statistically independent. Thirty-four (48 percent) of the 71 combinations were predicted adequately by an independent response hypothesis. A simple additive model was consistent with 39 (55 percent) of the observed responses, although 18 of these were among those in agreement with the independent hypothesis. A synergistic response faster than that predicted by either the independent or additive response model was seen in 12 (17 percent) of the combinations. The remaining 5 percent were not well described by any of these models. No strain was represented with unusual frequency among those involved in synergistic interactions.

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