Faculty Research 1980 - 1989
Analysis of growth hormone genes in mice with genetic defects of growth hormone expression.
Document Type
Article
Publication Date
1982
Keywords
Animal, Comparative-Study, Disease-Models-Animal, DNA: ge, Genes-Structural, Homozygote, Human, Hypopituitarism: fg, Leukocytes: an, Mice, Mice-Mutant-Strains: ge, Mutation, Somatotropin: ge, df, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S
First Page
405
Last Page
407
JAX Source
J-Endocrinol. 1982 Mar; 92(3):405-7.
Grant
AM00423, AM28246, AM17947
Abstract
Restriction endonuclease analysis of genomic DNA was carried out for three types of dwarf mice (Little, Ames dwarf and Snell dwarf) that have genetic defects in GH expression. We found the GH genes to be present in homozygotes for each mutant allele as well as in their control litter-mates. These three type of dwarf mice may be useful in studying the molecular basis of inherited GH deficiency and as models for analogous genetic disorders of human GH expression.
Recommended Citation
Phillips JA,
Beamer WG,
Bartke A.
Analysis of growth hormone genes in mice with genetic defects of growth hormone expression. J-Endocrinol. 1982 Mar; 92(3):405-7.