Faculty Research 1980 - 1989
Expression on normal lymphocytes of two cell surface antigens, XenCSA and GIX, related to the major glycoproteins (gp70) of murine leukemia viruses.
Document Type
Article
Publication Date
1982
Keywords
Antigens-Surface: ge, im, Chromosome-Mapping, Crosses-Genetic, Female, Lymphocytes: im, Male, Mice, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-DBA, Mice-Inbred-Strains, Mouse-Leukemia-Viruses: ge, im, Phenotype, Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S, Viral-Proteins: ge, im
First Page
2111
Last Page
2115
JAX Source
J-Immunol. 1982 May; 128(5):2111-5.
Grant
N01-CP-8-1054, N01-CP-33255
Abstract
XenCSA and GIX are two cell surface antigens related to the major envelope glycoproteins (gp70) of murine leukemia viruses. The levels of expression of these gp70 determinants were assessed in 36 recombinant inbred mouse strains and selected backcrosses derived from crosses between C57BL/6 with DBA/2 and C3H/He. These two antigens segregated in backcross mice and showed a different strain distribution pattern among the recombinant inbred mice, demonstrating that XenCSA and GIX are distinct genetic markers for different endogenous gp70 sequences. It was also shown that independent sets of gene regulate the expression of XenCSA and GIX.
Recommended Citation
Morse HC,
Taylor BA,
Kozak CA,
Chused TM,
Sharrow SO,
Hartley JW,
Stockert E.
Expression on normal lymphocytes of two cell surface antigens, XenCSA and GIX, related to the major glycoproteins (gp70) of murine leukemia viruses. J-Immunol. 1982 May; 128(5):2111-5.