Evidence for independent regulation of dolichol and cholesterol synthesis in developing mouse brain.

Authors

M J. James
A A. Kandutsch

Document Type

Article

Publication Date

1980

Keywords

Animals-Newborn: me, Brain: me, Cholesterol: bi, Diterpenes: bi, Dolichol: bi, In-Vitro, Mice, Mice-Inbred-DBA: me, SUPPORT-U-S-GOVT-P-H-S, Time-Factors

First Page

432

Last Page

435

JAX Source

Biochim-Biophys-Acta. 1980 Aug 11; 619(2):432-5.

Grant

CA02758

Abstract

In order to investigate the regulatory inter-relationships between the branching pathways of dolichol and cholesterol synthesis, we have measured the changing rates of synthesis for these two lipids in developing mouse brains. A sharp peak in the rate of dolichol synthesis occured at 3-7 days after birth which did not coincide with changes in cholesterol synthesis, suggesting independent regulation of dolichol and cholesterol synthesis in developing mouse brains.

Recommended Citation

James MJ, Kandutsch AA. Evidence for independent regulation of dolichol and cholesterol synthesis in developing mouse brain. Biochim-Biophys-Acta. 1980 Aug 11; 619(2):432-5.