Faculty Research 1980 - 1989
Requirement for the location of both appropriate and irrelevant H-2 antigens on the same stimulator cell for unspecific DNA-synthesis inhibition by the H-2-antigen-primed, specific suppressor T cells."
Document Type
Article
Publication Date
1982
Keywords
Crosses-Genetic", Cytotoxicity-Immunologic", DNA, H-2-Antigens, Lymphocyte-Culture-Test-Mixed", Mice, Mice-Inbred-A, Mice-Inbred-C57BL, Mice-Inbred-CBA, T-Lymphocytes, T-Lymphocytes-Suppressor-Effector
First Page
167
Last Page
176
JAX Location
see Journal Stacks
JAX Source
Immunogenetics 1982;15(2):167-76.
Abstract
Specific suppressor T cells (SSTC), primed in vivo with H-2 antigens, have been shown previously to inhibit DNA synthesis in the one-way, three-cell" mixed lymphocyte reaction (MLR) provided that (a) the stimulator cells bear the priming H-2 antigens, and (b) the responder cells possess IC + S" regions homologous to those of the SSTC. Anti-B10.A B10.A(2R) SSTC (anti-Dd) and anti-A.AL A.TL SSTC (anti-Kk) are shown here to be able to inhibit the DNA synthesis triggered in MLR, not only by the corresponding" antigens, Dd and Kk, respectively, but also by irrelevant, third-party H-2 and Mls products provided that the corresponding and third-party antigens are presented on the same stimulator cell. If stimulator H-2 regions," whose products interact with SSTC and responders, are located on different stimulator cells within the particular MLR, SSTC activity is not elicited. Participation of cytotoxic T lymphocytes in DNA-synthesis suppression is ruled out. Direct contact or location of the inhibited responder cell very close to SSTC is considered to be required for the development of SSTC activity.
Recommended Citation
Brondz BD,
Karaulov AV,
Chervonsky AV,
Blandova ZK.
Requirement for the location of both appropriate and irrelevant H-2 antigens on the same stimulator cell for unspecific DNA-synthesis inhibition by the H-2-antigen-primed, specific suppressor T cells." Immunogenetics 1982;15(2):167-76.