Faculty Research 1980 - 1989
Effects of arotinoids upon murine embryonal carcinoma cells.
Document Type
Article
Publication Date
1983
Keywords
Benzoates, Carrier-Proteins: me, Cell-Division: de, Cell-Line, Isomerism, Kinetics, Mice, Neoplasm-Proteins: me, Neoplasms-Experimental: pp, pa, Structure-Activity-Relationship, Teratoma: pp, pa, Tretinoin: me, Vitamin-A
First Page
4283
Last Page
4290
JAX Source
Cancer-Res. 1983 Sep; 43(9):4283-90.
Abstract
Five arotinoids have been compared with all-trans- and 13-cisretinoic acids for their ability to promote differentiation of cells from murine embryonal carcinoma line Nulli-SCC1. Ro-13-7410, which contains a terminal carboxylic acid residue, and Ro-14-9572, the sodium sulfinate derivative, are potent inducers of differentiation. The sodium sulfonate derivative, Ro-14-3899, is somewhat less active, whereas the ethyl sulfone (Ro-15-1570) and Ro-15-0778, an arotinoid lacking a terminal group, have little or no effect on embryonal carcinoma cell differentiation. Competition by the arotinoids with all-trans-retinoic acid for sites on the cellular retinoic acid-binding protein is qualitatively consistent with their capacity for promoting differentiation. This relationship and the response of differentiation-defective embryonal carcinoma cells to Ro-13-7410 support the view that arotinoids and retinoids promote differentiation of embryonal carcinoma cells via the same mechanism.
Recommended Citation
Sherman MI,
Paternoster ML,
Taketo M.
Effects of arotinoids upon murine embryonal carcinoma cells. Cancer-Res. 1983 Sep; 43(9):4283-90.