Faculty Research 1980 - 1989
Selective reversal of H-2 linked genetic unresponsiveness to lysozymes. I. Non-H-2 gene(s) closely linked to the Ir-2 locus on chromosome 2 permit(s) an antilysozyme response in H-2b mice.
Document Type
Article
Publication Date
1984
Keywords
Antibody-Formation, Chromosome-Mapping, Genes-Dominant, Genes-Immune-Response, H-2-Antigens: ge, Immunologic-Memory, Linkage-(Genetics), Lymphocyte-Transformation, Mice, Mice-Inbred-Strains: im, Muramidase: im, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S
First Page
535
Last Page
546
JAX Source
Immunogenetics. 1984; 20(5):535-46.
Grant
CA24442, AI11183
Abstract
Genes outside of the mouse major histocompatibility complex (H-2) were found to be capable of specifically reversing the previously described nonresponsiveness to hen egg-white lysozyme (HEL) owing to H-2b immune response (Ir) genes. C3H.SW, BALB.B, and C57L, all of the H-2b haplotype, showed responsiveness to HEL, but not to human lysozyme (HUL). Mapping of the reversing gene(s) was attempted by testing H-2b recombinant inbred (RI) strains of mice carrying C3H, BALB, and C57L non-H-2 genes. Analysis of the strain distribution pattern of responsiveness with both CXB and BXH RI strains was consistent with the location of the responsible site within the H-3 region on chromosome 2. The anti-HEL proliferative responsiveness in two H-3 congenic strains of mice, B10.C(28NX)SN and B10.C-H-3cH-3a, that have BALB/c genes within the H-3 region confirmed the mapping, as well as localized the reversing gene(s) near the Ir-2 gene. The data are discussed with regard to the site of expression of the reversing gene(s) and its mechanism of action.
Recommended Citation
Sadegh NS,
Kipp DE,
Taylor BA,
Miller A,
Sercarz E.
Selective reversal of H-2 linked genetic unresponsiveness to lysozymes. I. Non-H-2 gene(s) closely linked to the Ir-2 locus on chromosome 2 permit(s) an antilysozyme response in H-2b mice. Immunogenetics. 1984; 20(5):535-46.