Faculty Research 1980 - 1989
Expression of murine leukemia viruses in B-cell lymphomas of CWD/Agl mice.
Document Type
Article
Publication Date
1984
Keywords
B-Lymphocytes: mi, Brain: mi, Female, Genes-Viral, Leukemia-Experimental: mi, Lymphoma: mi, Male, Mice, Mice-Inbred-Strains, Mouse-Leukemia-Viruses: ge, py, Oncogenes, Species-Specificity, Spleen: mi, SUPPORT-U-S-GOVT-P-H-S
First Page
691
Last Page
694
JAX Location
277
JAX Source
J-Virol. 1984 Nov; 52(2):691-4.
Grant
09217
Abstract
The inbred mouse strain CWD/Agl has a high incidence of spontaneous B-cell lymphomas characterized by gross splenomegaly and lymph node enlargement. The endogenous ecotropic retrovirus of CWD/Agl mice is expressed in the spleen within the first 2 weeks of age and in the thymus by 1 month of age. Endogenous xenotropic virus is expressed in the spleen and bone marrow of the earliest age group examined (4 months). Restriction enzyme analysis of DNA extracted from tumorous tissues suggests that mink cell focus-forming viruses are not required for B-cell lymphomagenesis in CWD/Agl mice. CWD/Agl mice provide an important new experimental model for the study of B-cell lymphoma.
Recommended Citation
Angel JM,
Bedigian HG.
Expression of murine leukemia viruses in B-cell lymphomas of CWD/Agl mice. J-Virol. 1984 Nov; 52(2):691-4.