Faculty Research 1980 - 1989
Theophylline disposition in residents living near a chemical waste site.
Document Type
Article
Publication Date
1984
Keywords
Aminophylline: me, Biotransformation, Environmental-Pollution, Female, Human, Industrial-Waste, Kinetics, Male, Microsomes-Liver: en, Mixed-Function-Oxidases: me, New-York, Smoking, SUPPORT-U-S-GOVT-P-H-S, Theophylline: bl, me
First Page
345
Last Page
355
JAX Source
Biopharm Drug Dispos 1984 (Oct-Dec); 5(4):345-55.
Grant
20852
Abstract
The pharmacokinetics of theophylline were compared in 11 residents living near a chemical waste site (Love Canal) and 25 control subjects from Western New York. Love Canal residents had documented chronic exposure to a variety of organic and halogenated compounds. Only young adults with no overt diseases were examined. Theophylline plasma clearances were similar in the two groups, although the enzyme inductive effects of tobacco smoking were further confirmed. The lack of environmental effect on theophylline clearance indicates that no chronic net change in one pathway of microsomal P-448 oxidation occurred. The possibility of acute changes related to seasonal chemical exposure and mixed inductive/repressive effects from the myriad types of chemicals may confound the data.
Recommended Citation
Cuddy ML,
Gardner MJ,
Mangione A,
Yurchak AM,
Paigen B,
Jusko WJ.
Theophylline disposition in residents living near a chemical waste site. Biopharm Drug Dispos 1984 (Oct-Dec); 5(4):345-55.