Faculty Research 1980 - 1989
Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats.
Document Type
Article
Publication Date
1984
Keywords
Animal, Base-Sequence, Cattle, Cloning-Molecular, Comparative-Study, DNA-Insertion-Elements, Evolution, Fetus, Genes-Structural, Globin: ge, Goats, Nucleic-Acid-Hybridization, Repetitive-Sequences-Nucleic-Acid, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
1641
Last Page
1655
JAX Source
Nucleic Acids Res 1984 Feb 10;12(3):1641-55
Grant
HL1599611
Abstract
Bovine fetal and adult globin genes were cloned and subjected to DNA sequence analysis. Both of these genes contained insertions of Alu-type repetitive DNA within their introns. Comparison of cow and goat beta-type globin genes indicates that intragenic DNA insertions played a role in their evolution. These data support the theory that Alu-type repeats maintain genetic diversity by inhibiting gene conversion.
Recommended Citation
Schimenti JC,
Duncan CH.
Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats. Nucleic Acids Res 1984 Feb 10;12(3):1641-55