Faculty Research 1980 - 1989

Title

Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats.

Document Type

Article

Publication Date

1984

Keywords

Animal, Base-Sequence, Cattle, Cloning-Molecular, Comparative-Study, DNA-Insertion-Elements, Evolution, Fetus, Genes-Structural, Globin: ge, Goats, Nucleic-Acid-Hybridization, Repetitive-Sequences-Nucleic-Acid, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Nucleic Acids Res 1984 Feb 10;12(3):1641-55

Grant

HL1599611

Abstract

Bovine fetal and adult globin genes were cloned and subjected to DNA sequence analysis. Both of these genes contained insertions of Alu-type repetitive DNA within their introns. Comparison of cow and goat beta-type globin genes indicates that intragenic DNA insertions played a role in their evolution. These data support the theory that Alu-type repeats maintain genetic diversity by inhibiting gene conversion.

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