Faculty Research 1980 - 1989
Cellular genes in the mouse regulate in trans the expression of endogenous mouse mammary tumor viruses.
Document Type
Article
Publication Date
1985
Keywords
Animal, Cell-Transformation-Neoplastic, Comparative-Study, Female, Genes-Viral, Lipopolysaccharides, Mammary-Cancer-Virus: de, ge, Mice, Mice-Inbred-Strains, Nucleic-Acid-Hybridization, Oncogenes, RNA-Viral: ge, ip, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Transcription-Genetic
First Page
597
Last Page
615
JAX Source
Genetics. 1985 Nov; 111(3):597-615.
Grant
R01-CA-34823, R01-CA-28198, R01-GM-18684, +
Abstract
The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between the presence of a particular endogenous provirus or with increasing numbers of proviruses. Association of specific genetic markers with the level of MMTV-specific RNA was examined by using multiple regression analysis. Several cellular loci as well as proviral loci were identified that were significantly associated with viral expression. Importantly, these cellular loci associated with MMTV expression segregated independently of viral sequences.
Recommended Citation
Traina DV,
Carr JK,
Bailey WJ,
Elston RC,
Taylor BA,
Cohen JC.
Cellular genes in the mouse regulate in trans the expression of endogenous mouse mammary tumor viruses. Genetics. 1985 Nov; 111(3):597-615.