Faculty Research 1980 - 1989

Title

Cellular genes in the mouse regulate in trans the expression of endogenous mouse mammary tumor viruses.

Document Type

Article

Publication Date

1985

Keywords

Animal, Cell-Transformation-Neoplastic, Comparative-Study, Female, Genes-Viral, Lipopolysaccharides, Mammary-Cancer-Virus: de, ge, Mice, Mice-Inbred-Strains, Nucleic-Acid-Hybridization, Oncogenes, RNA-Viral: ge, ip, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Transcription-Genetic

JAX Source

Genetics. 1985 Nov; 111(3):597-615.

Grant

R01-CA-34823, R01-CA-28198, R01-GM-18684, +

Abstract

The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between the presence of a particular endogenous provirus or with increasing numbers of proviruses. Association of specific genetic markers with the level of MMTV-specific RNA was examined by using multiple regression analysis. Several cellular loci as well as proviral loci were identified that were significantly associated with viral expression. Importantly, these cellular loci associated with MMTV expression segregated independently of viral sequences.

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