Faculty Research 1980 - 1989
Linkage of loci affecting a murine liver protein and arylsulfatase B to chromosome 13.
Document Type
Article
Publication Date
1985
Keywords
Chondro-4-Sulfatase: ge, Chromosome-Mapping, Crosses-Genetic, Gene-Frequency, Genes-Structural, Linkage-(Genetics), Mice, Mice-Inbred-Strains, Molecular-Weight, Proteins: ge, Species-Specificity, Sulfatases: ge, SUPPORT-U-S-GOVT-P-H-S
First Page
243
Last Page
246
JAX Location
786
JAX Source
J-Hered. 1985 Jul-Aug; 76(4):243-6.
Grant
GM24265, GM27707, GM18684
Abstract
As-1 is the putative structural locus for murine arylsulfatase B, and Lth-1 determines the presence or absence of a 35 000 dalton acidic liver protein. As-1 and Lth-1 were found to be closely linked using recombinant inbred (RI) strains. Both loci were found to have been cotransferred with the pearl (pe) coat color mutation (chromosome 13) in the B6.C3H pe/pe congenic strain. The linkage relationships between pe, Lth-1, and As-1 were further defined in a backcross. On the basis of the RI data, the congenic strain result, and the backcross data, the following genetic distances were estimated: pe--As-1, 7.1 +/- 4.0 cM; As-1--Lth-1, 2.5 +/- 1.0 cM; and pe--Lth-1, less than 6.9 cM. As-1 and Lth-1 are the first biochemically defined loci to be added to the chromosome 13 linkage map.
Recommended Citation
Elliott RW,
Daniel WL,
Taylor BA,
Novak EK.
Linkage of loci affecting a murine liver protein and arylsulfatase B to chromosome 13. J-Hered. 1985 Jul-Aug; 76(4):243-6.