Faculty Research 1980 - 1989

Title

Linkage of loci affecting a murine liver protein and arylsulfatase B to chromosome 13.

Document Type

Article

Publication Date

1985

Keywords

Chondro-4-Sulfatase: ge, Chromosome-Mapping, Crosses-Genetic, Gene-Frequency, Genes-Structural, Linkage-(Genetics), Mice, Mice-Inbred-Strains, Molecular-Weight, Proteins: ge, Species-Specificity, Sulfatases: ge, SUPPORT-U-S-GOVT-P-H-S

JAX Location

786

JAX Source

J-Hered. 1985 Jul-Aug; 76(4):243-6.

Grant

GM24265, GM27707, GM18684

Abstract

As-1 is the putative structural locus for murine arylsulfatase B, and Lth-1 determines the presence or absence of a 35 000 dalton acidic liver protein. As-1 and Lth-1 were found to be closely linked using recombinant inbred (RI) strains. Both loci were found to have been cotransferred with the pearl (pe) coat color mutation (chromosome 13) in the B6.C3H pe/pe congenic strain. The linkage relationships between pe, Lth-1, and As-1 were further defined in a backcross. On the basis of the RI data, the congenic strain result, and the backcross data, the following genetic distances were estimated: pe--As-1, 7.1 +/- 4.0 cM; As-1--Lth-1, 2.5 +/- 1.0 cM; and pe--Lth-1, less than 6.9 cM. As-1 and Lth-1 are the first biochemically defined loci to be added to the chromosome 13 linkage map.

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