Faculty Research 1980 - 1989
Morphometric analysis of medial basal hypothalamic neuronal degeneration in diabetes (db/db) mutant C57BL/KsJ mice: relation to age and hyperglycemia.
Document Type
Article
Publication Date
1985
Keywords
Animal, Arcuate-Nucleus: pa, Blood-Glucose: an, Diabetes-Mellitus-Experimental: bl, fg, Female, Genotype, Mice, Mice-Inbred-C57BL, SUPPORT-U-S-GOVT-P-H-S, Ventromedial-Hypothalamic-Nucleus: pa
First Page
161
Last Page
168
JAX Source
Brain-Res. 1985 Jun; 352(2):161-8.
Grant
AM14461
Abstract
Age- and diabetes-related neuronal degenerative changes were morphometrically evaluated in the arcuate (ARC) and ventromedial (VMH) hypothalamic nuclei of control (+/?) and diabetic (db/db) C57BL/KsJ mice between 4 and 16 weeks of age. By 4 weeks of age, (db/db) mice exhibited marked obesity and hyperglycemia relative to controls. An increase in the population of degenerated ARC neurons was detected at 8 weeks of age in (db/db) mice relative to (+/?) animals. By 16 weeks of age, a significant increase in the number of degenerated VMH neurons in (db/db) mice was found, relative to controls. In addition, the neuronal density (neurons/mm2 area of nucleus) of both the ARC and VMH nuclei was found to be depressed in (db/db) mice, relative to controls, by 16 weeks of age. These data suggest that the normal degenerative loss of ARC and VMH neurons that occurs with age in normal mice is enhanced in the (db/db) mouse. These findings suggest that a functional alteration in hypothalamic nuclei which are recognized to modulate autonomic, pancreatic and pituitary activity may be associated with the onset or expression of the diabetic condition in the C57BL/KsJ (db/db) mouse.
Recommended Citation
Garris DR,
West RL,
Coleman DL.
Morphometric analysis of medial basal hypothalamic neuronal degeneration in diabetes (db/db) mutant C57BL/KsJ mice: relation to age and hyperglycemia. Brain-Res. 1985 Jun; 352(2):161-8.