Faculty Research 1980 - 1989

Tumor location using F(ab')2 mu from a monoclonal IgM antibody: pharmacokinetics.

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Antibodies-Monoclonal: du, Antigens-Neoplasm: im, Glycolipids: im, IgM, Immunoglobulins-Fab, Iodine-Radioisotopes: du, Kinetics, Mice, Mice-Inbred-BALB-C, Neoplasms-Experimental: ri, Plasmacytoma: ri, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Teratoma: ri, Time-Factors

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J Nucl Med 1985 Mar;26(3):283-92


HD12487, CA31784


A monoclonal IgM antibody (anti-SSEA-1) and its divalent antigen-binding peptic fragment [F(ab')2 mu] were compared as in vivo tumor localization reagents in mouse teratocarcinomas. F(ab')2 mu is cleared more rapidly than whole antibody from the whole body, blood, and all tested organs (t1/2 for whole antibody approximately 18 hr; t1/2 for F(ab')2 mu, 12 hr). A corresponding average improvement in tumor-to-tissue ratio is observed 48 hr after injection and earlier. However, the affinity of the F(ab')2 mu for antigen is much lower, and a smaller fraction of the antibody fragment is retained in the tumor than with whole antibody. The fragment was not retained by animals bearing nonantigenic tumors.

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