Faculty Research 1980 - 1989

Title

Tumor location using F(ab')2 mu from a monoclonal IgM antibody: pharmacokinetics.

Document Type

Article

Publication Date

1985

Keywords

Antibodies-Monoclonal: du, Antigens-Neoplasm: im, Glycolipids: im, IgM, Immunoglobulins-Fab, Iodine-Radioisotopes: du, Kinetics, Mice, Mice-Inbred-BALB-C, Neoplasms-Experimental: ri, Plasmacytoma: ri, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Teratoma: ri, Time-Factors

JAX Source

J Nucl Med 1985 Mar;26(3):283-92

Grant

HD12487, CA31784

Abstract

A monoclonal IgM antibody (anti-SSEA-1) and its divalent antigen-binding peptic fragment [F(ab')2 mu] were compared as in vivo tumor localization reagents in mouse teratocarcinomas. F(ab')2 mu is cleared more rapidly than whole antibody from the whole body, blood, and all tested organs (t1/2 for whole antibody approximately 18 hr; t1/2 for F(ab')2 mu, 12 hr). A corresponding average improvement in tumor-to-tissue ratio is observed 48 hr after injection and earlier. However, the affinity of the F(ab')2 mu for antigen is much lower, and a smaller fraction of the antibody fragment is retained in the tumor than with whole antibody. The fragment was not retained by animals bearing nonantigenic tumors.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS