A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on human chromosome 1.
Antibodies-Monoclonal: du, Antigenic-Determinants: ge, Antigens-Surface: ge, Cell-Line, Cell-Separation, Chromosome-Mapping, Chromosomes-Human-1-3, Flow-Cytometry, Human, Hybridomas, Mice, Precipitin-Tests, Radioimmunoassay, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
Ann Hum Genet 1985 Jan;49 ( Pt 1):31-9
An antigen expressed by most human cells, but not erythrocytes, has been defined by a murine monoclonal antibody, TRA-2-10. This antigen is expressed on the surface of human-mouse somatic cell hybrids, and segregation analysis indicates that it is controlled by a gene located on human chromosome 1. From lysates of most human cells, surface-labelled with 125I, TRA-2-10 immunoprecipitates two polypeptides with molecular weights in the range of about 55 000 to 73 000 depending upon the cell line. Since the TRA-2-10 polypeptides from a fibroblast cell strain and a hepatoma cell line from one individual differ, we conclude that the observed difference in molecular weight has an epigenetic origin.
Andrews, P W.; Knowles, B B.; Parkar, M; Pym, B; Stanley, K; and Goodfellow, P N., " A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on human chromosome 1." (1985). Faculty Research 1980 - 1989. 734.