Faculty Research 1980 - 1989
Chromosomal site of hepatitis B virus (HBV) integration in a human hepatocellular carcinoma-derived cell line.
Document Type
Article
Publication Date
1985
Keywords
Cell-Line, Chromosomes-Human-6-12, Hepatitis-B-Surface-Antigens: ge, Hepatitis-B-Virus: ge, Hepatoma: ge, mi, Human, Hybrid-Cells: cy, Karyotyping, Liver-Neoplasms: ge, mi, Liver-Neoplasms-Experimental: ge, Rats, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
116
Last Page
120
JAX Source
Cytogenet Cell Genet 1985;39(2):116-20
Grant
CA18460, CA37225, CA10815
Abstract
The single site of integration of hepatitis B virus in the human hepatocellular carcinoma cell line Hep 3B 2-1/7 was found to segregate with human chromosome 12 in somatic cell hybrids. Analysis of metaphase spreads of Hep 3B 2-1/7 following in situ hybridization with pHBV revealed integration at 12q13----q14, a location that coincides with a fragile site, fra (12q13). The possible significance of this location to the development of hepatocellular carcinomas is discussed.
Recommended Citation
Simon D,
Searls DB,
Cao Y,
Sun K,
Knowles BB.
Chromosomal site of hepatitis B virus (HBV) integration in a human hepatocellular carcinoma-derived cell line. Cytogenet Cell Genet 1985;39(2):116-20