Faculty Research 1980 - 1989
A fragment of the simian virus 40 early genome can induce tumors in nude mice.
Document Type
Article
Publication Date
1985
Keywords
Cell-Transformation-Neoplastic, Genes-Viral, Mice, Mice-Inbred-BALB-C, Mice-Nude, SUPPORT-U-S-GOVT-P-H-S, SV40-Virus: ge
First Page
988
Last Page
989
JAX Source
J Virol 1985 Mar;53(3):988-9
Grant
CA37303, CA21124, CA34072
Abstract
Cell lines transformed by simian virus 40 mutant F8dl (deleted from 0.168 to 0.424 map units, corresponding to the carboxy-terminal 62% of the wild-type simian virus 40 large tumor antigen) are tumorigenic in nude mice. Four of five C3H10T1/2 cell lines transformed by F8dl were tumorigenic in nude mice, whereas two of two wild-type transformants were tumorigenic.
Recommended Citation
Pan S,
Sompayrac LM,
Knowles BB,
Danna KJ.
A fragment of the simian virus 40 early genome can induce tumors in nude mice. J Virol 1985 Mar;53(3):988-9