Faculty Research 1980 - 1989
Mouse chromosome fragility.
Document Type
Article
Publication Date
1986
Keywords
Cells-Cultured, Chromosome-Banding, Chromosome-Fragile-Sites, Comparative-Study, Fluorodeoxyuridine, Genetic-Marker, Mice, Mice-Inbred-Strains: ge, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S
First Page
491
Last Page
509
JAX Source
Am-J-Med-Genet. 1986 Jan-Feb; 23(1-2):491-509.
Grant
HD17784, GM19656
Abstract
When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyuridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.
Recommended Citation
Sanz MM,
Jenkins EC,
Brown WT,
Davisson MT,
Kevin MJ,
Roderick TH,
Silverman WP,
Wisniewski HM.
Mouse chromosome fragility. Am-J-Med-Genet. 1986 Jan-Feb; 23(1-2):491-509.