Faculty Research 1980 - 1989
AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas.
Document Type
Article
Publication Date
1986
Keywords
DNA-Restriction-Enzymes, DNA-Neoplasm: ge, ip, Female, Genes-Structural, Immunoglobulins: ge, Lymphoma: fg, im, Mice, Mice-Inbred-Strains: ge, Nucleic-Acid-Hybridization, Receptors-Antigen-T-Cell: ge, Recombination-Genetic, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
4236
Last Page
4243
JAX Source
Mol-Cell-Biol. 1986 Dec; 6(12):4236-43.
Grant
CA37283, CA33093, NO1-CO-23909
Abstract
We analyzed the lymphoma susceptibility of 13 AKXD recombinant inbred mouse strains derived from AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 13 strains used, 12 showed a high incidence of lymphoma development. However, the average age at onset of lymphoma varied considerably among the different AKXD strains, suggesting that they have segregated several loci that affect lymphoma susceptibility. A relatively unambiguous classification of lymphomas was made possible by using histopathology in addition to detailed molecular characterization of rearrangements in immunoglobulin heavy and kappa light genes and in T-cell receptor beta-chain genes. Among the 12 highly lymphomatous strains, only 2 were identified that, like the parental AKR/J strain, died primarily of T-cell lymphomas. Three strains died primarily of B-cell lymphomas, and one strain primarily of myeloid lymphomas. Six strains were susceptible to both T-cell and B-cell lymphomas. Thus, these strains have segregated genes that affect both lymphoma susceptibility and lymphoma type and should prove to be useful models for studying the molecular genetic basis of murine lymphomas.
Recommended Citation
Mucenski ML,
Taylor BA,
Jenkins NA,
Copeland NG.
AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas. Mol-Cell-Biol. 1986 Dec; 6(12):4236-43.