Faculty Research 1980 - 1989
Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice.
Document Type
Article
Publication Date
1987
Keywords
Chromosome-Mapping, Diabetes-Mellitus-Insulin-Dependent Genes-Recessive, Islands-of-Langerhans, Mice, Mice-Inbred-Strains, Mice-Mutant-Strains, Polymorphism-(Genetics), Restriction-Fragment-Length-Polymorphisms
First Page
286
Last Page
289
JAX Source
Science. 1987 Jul 17; 237(4812):286-9.
Grant
AM36175, AM27722, AM14461
Abstract
A polygenic basis for susceptibility to insulin-dependent diabetes in nonobese diabetic (NOD) mice has been established by outcross to a related inbred strain, nonobese normal (NON). Analysis of first and second backcross progeny has shown that at least three recessive genes are required for development of overt diabetes. One, Idd-1s, is tightly linked to the H-2K locus on chromosome 17; another, Idd-2s, is localized proximal to the Thy-1/Alp-1 cluster on chromosome 9. Segregation of a third, Idd-3s, could be shown in a second backcross. Neither Idd-1s nor Idd-2s could individually be identified as the locus controlling insulitis; leukocytic infiltrates in pancreas were common in most asymptomatic BC1 mice. Both F1 and BC1 mice exhibited the unusually high percentage of splenic T lymphocytes characteristic of NOD, suggesting dominant inheritance of this trait. The polygenic control of diabetogenesis in NOD mice, in which a recessive gene linked to the major histocompatibility complex is but one of several controlling loci, suggests that similar polygenic interactions underlie this type of diabetes in humans.
Recommended Citation
Prochazka M,
Leiter EH,
Serreze DV,
Coleman DL.
Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science. 1987 Jul 17; 237(4812):286-9.