Faculty Research 1980 - 1989

Title

The structural gene for F liver protein (Flp) maps to chromosome 5 of the mouse.

Document Type

Article

Publication Date

1987

Keywords

Chromosome-Mapping, Genes-Structural, Genetic-Marker, Isoantigens: ge, Liver: im, Mice, Mice-Inbred-Strains, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Immunogenetics. 1987; 26(6):356-8.

Grant

GM18684

Abstract

The BXD and AKXL panels of recombinant inbred mouse strains have been typed for the F liver protein alloantigen. The structural gene for F liver protein gene (Flp) is placed on the distal part of chromosome 5, between the known markers Bcd-1 and Gus-s. This excludes the possibility that F liver protein is a major histocompatibility complex molecule, and in turn raises a question about the uniqueness of F and certain other proteins as purgers of self-reactivity among T but not B cells. The typed RI strains have then been used for the immunogenetic studies presented in the succeeding article.

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