Faculty Research 1980 - 1989
Relationship of the genes for Chediak-Higashi syndrome (beige) and the T-cell receptor gamma chain in mouse and man.
Document Type
Article
Publication Date
1987
Keywords
Chediak-Higashi-Syndrome: fg, im, Evolution, Female, Human, Linkage-(Genetics), Male, Mice, Pedigree, Receptors-Antigen-T-Cell: ge, Restriction-Fragment-Length-Polymorphisms, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
287
Last Page
291
JAX Source
Genomics 1987 Nov; 1(3):287-91.
Grant
HL07446, AI19148, AI18436, +
Abstract
The genetic linkage of Chediak-Higashi syndrome and its murine analog, beige (bg), to the T-cell receptor (TCR-gamma) gamma chain gene is further defined. Previous studies using recombinant inbred strains of mice demonstrated that the murine bg gene is genetically linked to a murine TCR-gamma gene. We report that in the mouse the frequency of recombination between these two markers is 0.025. Further, we tested the hypothesis that these two genes are linked in the human genome by analyzing restriction fragment length polymorphisms (RFLPs) in five families with children afflicted with Chediak-Higashi syndrome. In three families, RFLPs in TCR-gamma genes were inherited discordantly from Chediak-Higashi syndrome, demonstrating nonlinkage. We postulate that there is an evolutionary chromosomal breakpoint between the bg gene and the TCR-gamma gene.
Recommended Citation
Holcombe RF,
Strauss W,
Owen FL,
Boxer LA,
Warren RW,
Conley ME,
Ferrara J,
Leavitt RY,
Fauci AS,
Taylor BA.
Relationship of the genes for Chediak-Higashi syndrome (beige) and the T-cell receptor gamma chain in mouse and man. Genomics 1987 Nov; 1(3):287-91.