Faculty Research 1980 - 1989
Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors.
Document Type
Article
Publication Date
1988
Keywords
Chromosome-Mapping, Crosses-Genetic, Epidermal-Growth-Factor-Urogastrone: ge, Leukemia-Experimental: fg, me, mi, Leukemia-Myelocytic: fg, me, mi, Mice, Mice-Inbred-A, Mice-Inbred-AKR, Mice-Inbred-BALB-C, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-DBA, Proto-Oncogenes, Recombination-Genetic, Restriction-Fragment-Length-Polymorphisms, Retroviridae: me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
219
Last Page
233
JAX Location
1809
JAX Source
Oncogene Res 1988 Feb; 2(3):219-33.
Grant
CA37283, CA33093, NO1-CO-23909
Abstract
The chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myelogenous leukemias, was determined by recombinant inbred and conventional backcross analyses. We mapped Evi-1 to a location approximately 15 cM distal to the carbonic anhydrase locus on murine Chromosome 3. The chromosomal location of the proto-oncogene Nras, and two growth factors, epidermal growth factor (Egf), and the beta subunit of nerve growth factor (Ngfb), which had previously been assigned to Chromosome 3 by somatic cell hybrid analysis, were also determined. The location of Evi-1 is distinct from these three loci and from all other proto-oncogenes, common sites of viral integration, or growth factor loci previously mapped in mouse chromosomes. These results suggest that Evi-1 represents a new locus involved in myeloid disease.
Recommended Citation
Mucenski ML,
Taylor BA,
Copeland NG,
Jenkins NA.
Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors. Oncogene Res 1988 Feb; 2(3):219-33.