Faculty Research 1990 - 1999
Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T-antigen hybrid gene.
Document Type
Article
Publication Date
1990
Keywords
Animal, Antigens-Polyomavirus-Transforming: ge, me, Bone-Neoplasms: ge, me, pa, Cell-Line, Cloning-Molecular, Mice, Mice-Transgenic: ge, Osteosarcoma: ge, me, pa, Promoter-Regions-(Genetics), SUPPORT-U-S-GOVT-P-H-S, Tumor-Cells-Cultured: me, pa
First Page
259
Last Page
262
JAX Source
Am J Pathol 1990 Aug;137(2):259-62
Grant
CA10815/CA/NCI, CA18470/CA/NCI, CA21124/CA/NCI
Abstract
Mice of a transgenic mouse lineage 501, produced by zygotic injection of the parotid alpha-amylase promoter-SV40 T-antigen hybrid gene, developed osteosarcomas at about 15 months of age. The tumors predominantly involved the axial skeleton, were sometimes multiple, and metastasized to the liver. A cell line derived from a primary tumor produced osteosarcomas on transfer to nude mice. The 501 transgenic lineage thus provides a valuable new model for studying the histogenesis of osteosarcomas.
Recommended Citation
Knowles BB,
McCarrick J,
Fox N,
Solter D,
Damjanov I.
Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T-antigen hybrid gene. Am J Pathol 1990 Aug;137(2):259-62