Faculty Research 1990 - 1999
Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.
Document Type
Article
Publication Date
1998
First Page
556
Last Page
559
JAX Source
Genomics 1998 Dec 15;54(3):556-9
Grant
P40RR01183/RR/NCRR, 37GM36745/GM/NIGMS
Abstract
Patchy fur is a semidominant X-linked mutation in the mouse, resulting in a sparse coat. The Paf mutation also alters the normal segregation of the X and the Y chromosomes during male meiosis by causing nondisjunction at anaphase I. Analysis of 1139 female meioses from an intersubspecific backcross using 15 PCR-based markers localizes Paf to an approximately 0.2-cM interval that includes the pseudoautosomal boundary. The meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing. Copyright 1998 Academic Press.
Recommended Citation
Korobova O,
Lane PW,
Perry J,
Palmer S,
Ashworth A,
Davisson MT,
Arnheim N.
Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region. Genomics 1998 Dec 15;54(3):556-9