Faculty Research 1990 - 1999

A new dominant neurological mutant induced in the mouse by ethylene oxide.

Document Type

Article

Publication Date

1990

Keywords

Animal, Behavior-Animal, Cataract: ge, Ethylene-Oxide: to, Genes-Dominant, Karyotyping, Litter-Size, Male, Maternal-Behavior, Mice, Mice-Inbred-C57BL, Mice-Inbred-DBA, Motor-Activity, Sex-Factors, SUPPORT-U-S-GOVT-P-H-S, Swimming, Translocation-(Genetics)

First Page

135

Last Page

139

JAX Location

Reprint Collection : 1923

JAX Source

Mutat Res 1990 Apr; 229(2):135-9.

Grant

N01-ES-55078

Abstract

This paper describes a dominant neurological mutation identified among the progeny of a male parent treated with ethylene oxide. The defects observed in the heterozygous mutant include: head tossing, poor limb coordination, and corneal clouding. Both the behavior and ocular manifestations of the mutant syndrome worsen progressively as the affected animals grow older. The mutant animals swim poorly, although they do orient themselves in reference to the surface of the water. Breeding in general is poor. Very small litter sizes result when heterozygous animals of either sex are mated to normal mice. Many male carriers are functionally sterile. All mutant animals had abnormal karyotypes. The original carrier mouse had a translocation between Chromosomes 4 and 17, which was also present in all but one mutant animal. The exceptional animal, which showed all mutant behavioral characteristics, had 41 chromosomes which included two normal 4 and 17 homologs and the small 4(17) translocation chromosome. Karyotypes of unaffected siblings of mutants were normal. Because the small translocation chromosome appears to be inseparably associated with the mutant phenotype, we have named the mutation translocation induced circling mutation symbol, Tim.

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