Faculty Research 1990 - 1999
Expression of Melk, a new protein kinase, during early mouse development.
Document Type
Article
Publication Date
1999
Keywords
Conserved-Sequence, Female, Fetal-Development, Gastrula, Gene-Expression-Regulation-Developmental, Germ-Cells, Immunohistochemistry, In-Situ-Hybridization, Mice, Models-Genetic, Molecular-Sequence-Data, Postimplantation-Phase, Pregnancy, Preimplantation-Phase, Protein-Kinases, Protein-Serine-Threonine-Kinases, Reverse-Transcriptase-Polymerase-Chain-Reaction, SUPPORT-NON-U-S-GOVT, Time-Factors, Tissue-Distribution
First Page
344
Last Page
351
JAX Source
Dev Dyn 1999 Aug; 215(4):344-351.
Abstract
A new gene named maternal embryonic leucine zipper kinase, Melk, has been recently identified (Heyer et al. [1997] Mol. Reprod. Dev.47:148-156). As a basis for further study of the function of the gene, we have examined the expression of Melk across a wide range of embryonic stages, from the ovulated egg and 2-cell embryo through the gastrulation and early organogenesis stages, by in situ hybridization and immunohistochemistry. Melk is expressed in a spatially and temporally specific pattern during mammalian embryogenesis. The strongest expression was detected during maturation of oocytes and preimplantation development. Given its expression pattern, Melk may play an important role during preimplantation embryonic development. Dev Dyn 1999;215:344-351. Copyright 1999 Wiley-Liss, Inc.
Recommended Citation
Heyer BS,
Kochanowski H,
Solter D.
Expression of Melk, a new protein kinase, during early mouse development. Dev Dyn 1999 Aug; 215(4):344-351.