Faculty Research 1990 - 1999
The immunodeficient scid mouse as a model for human lymphatic filariasis.
Document Type
Article
Publication Date
1991
Keywords
Brugia, Disease-Models-Animal, Elephantiasis-Filarial: im, pa, Human, Immunoglobulins: ge, Immunologic-Deficiency-Syndromes: ge, co, Inflammation, Lymphocyte-Subsets: im, Mice, Mice-Mutant-Strains, Receptors-Antigen-T-Cell: ge, Spleen: im, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
659
Last Page
663
JAX Source
J Exp Med 1991 Mar 1; 173(3):659-63.
Grant
AI30046, AI30389, CA20408
Abstract
The C.B.-17-scid/scid mouse (hereafter referred to as the scid mouse) is homozygous for a recessive mutation at a locus that influences the assembly of intact immunoglobulin and T cell receptor genes. Therefore, scid mice cannot generate functional B or T lymphocytes, are profoundly immunodeficient, and have been reported to be receptive to reconstitution with human immune cells. In the present study, we injected scid mice with infective larvae of the human filarial parasite Brugia malayi. Within 6-10 wk after subcutaneous injection of infective L3 larvae, both male and female worms were observed in various stages of development in 90% of the mice. In animals tested 8 weeks or more after infection, microfilariae were detected in the blood or peritoneal cavity of 52% of the mice examined. Adult worms were observed in the lymphatics of the infected scid mice, where their presence was associated with lymphangitis and lymphangiectasia. These results suggest that the scid mouse model of lymphatic filariasis may be important in investigation of the interaction of the murine, and possibly the human, immune system with the lymphatic filarial parasite.
Recommended Citation
Nelson FK,
Greiner DL,
Shultz LD,
Rajan TV.
The immunodeficient scid mouse as a model for human lymphatic filariasis. J Exp Med 1991 Mar 1; 173(3):659-63.