Faculty Research 1990 - 1999
Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host.
Document Type
Article
Publication Date
1999
Keywords
Case-Report, Facial-Dermatoses, Hair-Diseases, Hair-Follicle, Human, Immunocompromised-Host, Male, Papovaviridae-Infections, SUPPORT-NON-U-S-GOVT
First Page
268
Last Page
271
JAX Source
J Investig Dermatol Symp Proc 1999 Dec; 4(3):268-71.
Abstract
This is a case report of an immunocompromised individual who presented with progressive alopecia, friable follicular spinous processes, and erythematous, indurated papules. Examination of skin biopsies using light microscopy and immunohistochemistry revealed pathologic changes of the follicular inner root sheath epithelium with dystrophic trichohyaline granules. Electron microscopy of thin sections of tissue revealed intracellular viral particles with a size and appearance consistent with those in the Papovaviridae family. Electron microscopy of negatively stained extract from a homogenized lesion also demonstrated icosahedral viruses with papovavirus morphology. We believe this is a previously unreported folliculocentric viral infection in an immunosuppressed human host and have termed this entity "trichodysplasia spinulosa".
Recommended Citation
Haycox CL,
Kim S,
Fleckman P,
Smith LT,
Piepkorn M,
Sundberg JP,
Howell DN,
Miller SE.
Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host. J Investig Dermatol Symp Proc 1999 Dec; 4(3):268-71.