Faculty Research 1990 - 1999
Genes for epilepsy mapped in the mouse.
Document Type
Article
Publication Date
1991
Keywords
Chromosome-Mapping, Crosses-Genetic, Disease-Susceptibility: ge, Epilepsy: ge, Female, Male, Mice, Mice-Inbred-Strains, Mice-Neurologic-Mutants: ge, Recombination-Genetic, Seizures: ge, Software, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
669
Last Page
673
JAX Source
Science 1991 Aug 9; 253(5020):669-73.
Grant
NS23355
Abstract
The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.
Recommended Citation
Rise ML,
Frankel WN,
Coffin JM,
Seyfried TN.
Genes for epilepsy mapped in the mouse. Science 1991 Aug 9; 253(5020):669-73.